Biological Activity
More active enantiomer of (±)-U-50488 (Cat. No. 0495). (+)-U-50488 hydrochloride (Cat. No. 0471) also available.
Compound Libraries
(-)-U-50488 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 405.79 |
| Formula | C19H26Cl2N2O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 114528-79-9 |
| PubChem ID | 9931141 |
| InChI Key | KGMMGVIYOHGOKQ-APTPAJQOSA-N |
| Smiles | O=C(CC3=CC(Cl)=C(Cl)C=C3)N([C@@H]1[C@@H](N2CCCC2)CCCC1)C.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.58 | 100 | |
| water | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 405.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.46 mL | 12.32 mL | 24.64 mL |
| 5 mM | 0.49 mL | 2.46 mL | 4.93 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.46 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
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References
References are publications that support the products' biological activity.
De Costa et al (1987) Synthesis and absolute configuration of optically pure enantiomers of a κ-opioid receptor selective antagonist. FEBS Lett. 223 335 PMID: 2822490
Morrone et al (1993) Withdrawal contractures of guinea-pig isolated ileum after acute activation of κ opioid receptors. Br.J.Pharmacol. 109 48 PMID: 8388301
Reddy and Bhargava (1993) Effect of chronic administration of U-50,488H, a kappa opioid receptor agonist on central dopamine (D2) receptors of the rat. Eur.J.Pharmacol. 235 23 PMID: 8390939
Zhu et al (1998) Agonist-induced desensitization and down-regulation of the human kappa opioid receptor expressed in chinese hamster ovary cells. J.Pharmacol.Exp.Ther. 285 28 PMID: 9535991
Keywords: (-)-U-50488 hydrochloride, supplier, selective, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, Kappa, Opioid, Receptors, Kappa, Opioid, Receptors, Tocris Bioscience
