Biological Activity
κ-opioid agonist and anticonvulsant. Perhaps acts as an NMDA antagonist.
Technical Data
| M. Wt | 391.77 |
| Formula | C18H24Cl2N2O.HCl |
| Storage | Store at RT |
| CAS Number | 112465-94-8 |
| PubChem ID | 183470 |
| InChI Key | JUBNVWGVNWIXMB-SJORKVTESA-N |
| Smiles | O=C(C3=CC(Cl)=C(Cl)C=C3)N([C@H]1[C@@H](N2CCCC2)CCCC1)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.18 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 391.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.76 mL | 25.53 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.11 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
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Product Datasheets
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References
References are publications that support the products' biological activity.
Proietti et al (1991) In vitro depressant effects of U-54494A, an anticonvulsant related to kappa opioids in the hippocampus. Neuropharmacology 30 637 PMID: 1656303
Sethy and Sage (1992) Modulation of release of acetylcholine from the striatum by a proposed excitatory amino acid antagonist U-54494A: comparison with known antagonists, diazepam and phenytoin. Neuropharmacology 31 111 PMID: 1348110
Voigtlander et al (1987) U-54494A: a unique anticonvulsant related to kappa opioid agonists. J.Pharmacol.Exp.Ther. 243 542 PMID: 2824750
Keywords: U-54494A hydrochloride, supplier, agonists, κ-opioid, kappa-opioid, KOP, Receptors, OP2, Kappa, Opioid, Receptors, Kappa, Opioid, Receptors, Tocris Bioscience
