Biological Activity
AMPA and kainate receptor antagonist. Inhibits AMPA receptor-, but not kainate receptor-mediated currents on spinal neonatal motoneurons yet antagonizes kainate-induced responses on dorsal root C-fibres.
Technical Data
| M. Wt | 333.3 |
| Formula | C15H15N3O6 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 544697-47-4 |
| PubChem ID | 6604912 |
| InChI Key | XLRLZPOBHPIDFX-NSHDSACASA-N |
| Smiles | O=C(C=CN1C[C@H](N)C(O)=O)N(CC2=CC=C(C(O)=O)C=C2)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 8.33 | 25 | |
| 1eq. NaOH | 33.33 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 333.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3 mL | 15 mL | 30 mL |
| 5 mM | 0.6 mL | 3 mL | 6 mL |
| 10 mM | 0.3 mL | 1.5 mL | 3 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
More et al (2002) The novel antagonist 3-CBW discriminates between kainate receptors expressed on neonatal rat motoneurones and those on dorsal root C-fibres. Br.J.Pharmacol. 137 1125 PMID: 12429586
More et al (2003) Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists. Br.J.Pharmacol. 138 1093 PMID: 12684265
Keywords: UBP 282, supplier, AMPA/kainate, antagonists, receptors, Glutamate, AMPA, iGluR, Ionotropic, Kainate, UBP282, 3CBW, 3-CBW, AMPA, Receptors, Kainate, Receptors, AMPA, Receptors, Tocris Bioscience
