Biological Activity
Potent kainate receptor antagonist (apparent Kd = 5.94 μM). Displays ~ 30-fold selectivity over AMPA receptors.
Technical Data
| M. Wt | 459.2 |
| Formula | C15H14IN3O6 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 569371-10-4 |
| PubChem ID | 6604913 |
| InChI Key | JHSYCOCOIYSZGI-NSHDSACASA-N |
| Smiles | O=C(C(I)=CN1C[C@H](N)C(O)=O)N(CC2=CC=C(C(O)=O)C=C2)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.3 | 5mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 459.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.18 mL | 10.89 mL | 21.78 mL |
| 5 mM | 0.44 mL | 2.18 mL | 4.36 mL |
| 10 mM | 0.22 mL | 1.09 mL | 2.18 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
More et al (2003) Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists. Br.J.Pharmacol. 138 1093 PMID: 12684265
Keywords: UBP 301, supplier, Kainate, receptor, antagonists, Glutamate, Receptors, iGluR, Ionotropic, UBP301, Kainate, Receptors, Kainate, Receptors, Tocris Bioscience
