Biological Activity
A selective group III mGlu receptor antagonist (apparent Kd values are 5.1 and 488 μM for group III and group II mGlu receptors respectively; IC50 > 1 mM for group I, NMDA, AMPA and kainate receptors).
Technical Data
| M. Wt | 259.2 |
| Formula | C10H14NO5P |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 339526-74-8 |
| PubChem ID | 5022489 |
| InChI Key | LLEOLNUKLKCAFG-UHFFFAOYSA-N |
| Smiles | NC(C(O)=O)(C)C1=CC=C(P(O)(O)=O)C(C)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in 1eq. NaOH |
Preparing Stock Solutions
The following data is based on the product molecular weight 259.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.86 mL | 19.29 mL | 38.58 mL |
| 5 mM | 0.77 mL | 3.86 mL | 7.72 mL |
| 10 mM | 0.39 mL | 1.93 mL | 3.86 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.77 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Conway et al (2001) Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors. Bioorg.Med.Chem.Lett. 11 777 PMID: 11277518
Miller et al (2003) Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals. Br.J.Pharmacol. 139 1523 PMID: 12922940
Keywords: UBP1112, supplier, Group, III, antagonists, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGlu4R, mGlu6R, mGlu7R, mGlu8R, Glutamate, Metabotropic, UBP, 1112, Glutamate, (Metabotropic), Group, III, Receptors, Glutamate, (Metabotropic), Group, III, Receptors, Tocris Bioscience
