Biological Activity
Class I HDAC inhibitor (IC50 values are 0.06, 0.1, 0.5 and 1.5 μM for HDACs 3, 2, 1 and 8, respectively). Exhibits >6-fold selectivity over other HDACs. Induces accumulation of acetylated histones in HCT116 cells in vitro. Inhibits proliferation of a range of cancer cell lines. Arrests cells at G1/S transition.
Compound Libraries
UF 010 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 271.15 |
| Formula | C11H15BrN2O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 537672-41-6 |
| PubChem ID | 4596836 |
| InChI Key | BVQCFCYPFJOOAV-UHFFFAOYSA-N |
| Smiles | BrC1=CC=C(C(NNCCCC)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.11 | 100 | |
| ethanol | 27.11 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 271.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.69 mL | 18.44 mL | 36.88 mL |
| 5 mM | 0.74 mL | 3.69 mL | 7.38 mL |
| 10 mM | 0.37 mL | 1.84 mL | 3.69 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Wang et al (2015) Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. Chem.Biol. 22 273 PMID: 25699604
Keywords: UF 010, supplier, UF010, histone, deacetylase, inhibitors, inhibits, HDAC, classI, cancer, proliferation, cell, cycle, arrest, antiproliferative, epigenetics, Histone, Deacetylases, Histone, Deacetylases, Tocris Bioscience
