Biological Activity
Water-soluble form of UK 14,304 (Cat. No. 0425). Full α2 adrenergic agonist. Centrally active following systemic administration in vivo.
Technical Data
| M. Wt | 442.23 |
| Formula | C11H10BrN5.C4H6O6 |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 70359-46-5 |
| PubChem ID | 11236066 |
| InChI Key | QZHBYNSSDLTCRG-UHFFFAOYSA-N |
| Smiles | O=C(O)C(O)C(O)C(O)=O.BrC2=C(NC3=NCCN3)C=CC1=NC=CN=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 22.11 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 442.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.26 mL | 11.31 mL | 22.61 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.52 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.26 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Cambridge (1981) UK-14,304, a potent and selective alpha2-gonist for the characterisation of alpha-adrenoceptor subtypes. Eur.J.Pharmacol. 72 413 PMID: 6115759
Andorn et al (1988) Specific [3H]UK-14,304 binding in human cortex occurs at multiple high affinity states with α2-adrenergic selectivity and different affinities for GTP. Life Sci. 43 1805 PMID: 2904634
Macdonald et al (1997) Gene targeting - homing in on α2-adrenoceptor-subtype function. TiPS 18 211 PMID: 9227000
Chopin et al (1999) Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J.Pharmacol.Exp.Ther. 288 798 PMID: 9918591
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