BiologicalActivity
SelectiveinhibitorofG9aandGLPhistonelysinemethyltransferases(IC50valuesare<15nMand19nMforG9aandGLPrespectively,and>10000nMforarangeofotherhistonemethyltransferases).PotentlyinhibitsdimethylationofH3K9inMCF-7cells(IC50=70nM).Cellpermeable.
LicensingInformation
ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheUNC0638probesummaryontheSGCwebsite.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofUNC0638isreviewedonthechemicalprobeswebsite.
CompoundLibraries
UNC0638isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 509.73 |
| Formula | C30H47N5O2 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 1255517-77-1 |
| PubChemID | 46224516 |
| InChIKey | QOECJCJVIMVJGX-UHFFFAOYSA-N |
| Smiles | CC(C)N(CC5)CCC5NC1=C2C(C=C(OCCCN4CCCC4)C(OC)=C2)=NC(C3CCCCC3)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 50.97 | 100 | |
| DMSO | 50.97 | 100 | |
| ethanol | 50.97 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight509.73.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.96mL | 9.81mL | 19.62mL |
| 5mM | 0.39mL | 1.96mL | 3.92mL |
| 10mM | 0.2mL | 0.98mL | 1.96mL |
| 50mM | 0.04mL | 0.2mL | 0.39mL |
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ProductDatasheets
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