Biological Activity
Potent and selective PIP5K1C inhibitor (IC50 = 41 nM). Exhibits selectivity for PIP5K1C over PIP5K1A, the PI 3-kinase family and a panel of other kinases. Reduces PIP2 levels and LPA-induced calcium signaling in dorsal root ganglia (DRG) neurons in vitro. Reduces nociception in mouse models of chronic pain.
Compound Libraries
UNC 3230 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 344.43 |
| Formula | C17H20N4O2S |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1031602-63-7 |
| PubChem ID | 46355372 |
| InChI Key | RZCNASHHHSKTGP-UHFFFAOYSA-N |
| Smiles | O=C(N)C1=C(NC(C2CCCCC2)=O)SC(NC3=CC=CC=C3)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.44 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 344.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.9 mL | 14.52 mL | 29.03 mL |
| 5 mM | 0.58 mL | 2.9 mL | 5.81 mL |
| 10 mM | 0.29 mL | 1.45 mL | 2.9 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Wright et al (2014) The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron 82 836 PMID: 24853942
Keywords: UNC 3230, supplier, UNC3230, potent, selective, PIP5K1C, inhibitors, inhibits, antinociceptive, reduces, nociception, chronic, pain, phosphatidylinositol-4-phosphate, 5-kinase, type, I, gamma, Other, Kinases, Other, Kinases, Tocris Bioscience
