Biological Activity
Potent and selective fatty acid amide hydrolase (FAAH) inhibitor (IC50 values are 3 and 5 nM in human liver and rat brain, respectively). Exhibits no significant inhibitory activity against a variety of receptors, ion channels and enzymes, including human cannabinoid receptors and rat monoacylglycerol lipase. Displays antiallodynic and antihyperalgesic activity in an inflammatory pain model.
Compound Libraries
URB 597 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 338.4 |
| Formula | C20H22N2O3 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 546141-08-6 |
| PubChem ID | 1383884 |
| InChI Key | ROFVXGGUISEHAM-UHFFFAOYSA-N |
| Smiles | NC(C1=CC(C2=CC=CC(OC(NC3CCCCC3)=O)=C2)=CC=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.92 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 338.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.96 mL | 14.78 mL | 29.55 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.91 mL |
| 10 mM | 0.3 mL | 1.48 mL | 2.96 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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References
References are publications that support the products' biological activity.
Hohmann et al (2005) An endocannabinoid mechanism for stress-induced analgesia. Nature 435 1108 PMID: 15973410
Piomelli et al (2006) Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS Drug Rev. 12 21 PMID: 16834756
Jayamanne et al (2006) Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. Br.J.Pharmacol. 147 281 PMID: 16331291
Keywords: URB 597, supplier, URB597, faah, fatty, acid, amide, hydrolase, inhibitors, inhibits, selective, potent, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Cannabinoids, Fatty, Acid, Amide, Hydrolase, (FAAH), Tocris Bioscience
