Biological Activity
Non-competitive MAGL inhibitor. Exhibits selectivity for MAGL over FAAH, diacylglycerol lipase and COX2. Blocks 2-AG hydrolysis in rat brain slices. Enhances stress-induced analgesia in rats.
Technical Data
| M. Wt | 295.38 |
| Formula | C19H21NO2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 565460-15-3 |
| PubChem ID | 10979337 |
| InChI Key | HHVUFQYJOSFTEH-UHFFFAOYSA-N |
| Smiles | O=C(OC1CCCCC1)NC2=CC=CC(C3=CC=CC=C3)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.54 | 100 | |
| ethanol | 29.54 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 295.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.39 mL | 16.93 mL | 33.85 mL |
| 5 mM | 0.68 mL | 3.39 mL | 6.77 mL |
| 10 mM | 0.34 mL | 1.69 mL | 3.39 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Hohmann et al (2005) An endocannabinoid mechanism for stress-induced analgesia. Nature. 435 1108 PMID: 15973410
Makara et al (2005) Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. Nat.Neurosci. 8 1139 PMID: 16116451
Keywords: URB 602, supplier, URB602, non-competitive, MAGL, inhibitors, inhibits, monoacylglycerol, lipases, MAGL, MAGL, Tocris Bioscience
