![Tocris/[Orn5]-URP/3162/1/1 mg](https://www.ebiomall.cn/images/201712/1512520078951260693.jpg)
Biological Activity
Urotensin-II (UT) receptor pure antagonist (pEC50 = 7.24). Displays no agonist activity unlike other U-II/URP analogs. Inhibits the action of U-II in the rat aorta ring assay.
Technical Data
| M. Wt | 1003.2 |
| Formula | C48H62N10O10S2 |
| Sequence |
ACFWXYCV (Modifications: X = Orn, Disulfide bridge between 2 - 7) |
| Storage | Store at -20°C |
| CAS Number | 782485-03-4 |
| PubChem ID | 90488807 |
| InChI Key | BPLKRLYKWHXTMO-LSKWFVNGSA-N |
| Smiles | [H]N[C@@H](C)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](CCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC1=O)C(=O)N[C@@H](C(C)C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1003.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1 mL | 4.98 mL | 9.97 mL |
| 5 mM | 0.2 mL | 1 mL | 1.99 mL |
| 10 mM | 0.1 mL | 0.5 mL | 1 mL |
| 50 mM | 0.02 mL | 0.1 mL | 0.2 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Chatenet et al (2004) Structure-activity relationships and structural conformation of a novel urotensin II-related peptide. Peptides 25 1819 PMID: 15476952
Diallo et al (2008) [Orn5]URP acts as a pure antagonist of urotensinergic receptors in rat cortical astrocytes. Peptides 29 813 PMID: 18082287
Keywords: [Orn5]-URP, supplier, Urotensin-II, UT, receptor, antagonists, Receptors, Urotensin-II, Receptors, Urotensin-II, Receptors, Tocris Bioscience
