Biological Activity
Neuropeptide with many biological actions; plays a role in neurotransmission, smooth muscle relaxation and has trophic and mitogenic actions.
Technical Data
| M. Wt | 3346 |
| Formula | C147H239N43O42S2 |
| Sequence |
HSDALFTDTYTRLRKQMAMKKYLNSVLN (Modifications: Asn-28 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 96886-24-7 |
| PubChem ID | 90477828 |
| InChI Key | UGKBLTCXYMBLJU-SDELKSRWSA-N |
| Smiles | [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 3346. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.3 mL | 1.49 mL | 2.99 mL |
| 5 mM | 0.06 mL | 0.3 mL | 0.6 mL |
| 10 mM | 0.03 mL | 0.15 mL | 0.3 mL |
| 50 mM | 0.01 mL | 0.03 mL | 0.06 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Fahrenkrug (1993) Transmitter role of vasoactive intestinal peptide. Pharmacol.Toxicol. 72 354 PMID: 8103215
Gressens et al (1998) Vasoactive intestinal peptide shortens both G1 and S phases of neural cell cycle in whole postimplantation cultured mouse embryos. Eur.J.Neurosci. 10 1734 PMID: 9751145
Motomura et al (1998) Interactive mechanisms among pituitary adenylate cyclase-activating peptide, vasoactive intestinal peptide, and parathyroid hormone receptors in guinea pig cecal circular smooth muscle cells. Endocrinology 139 2869 PMID: 9607796
Keywords: VIP (guinea pig), supplier, Involved, neurotransmission, smooth, muscle, relaxation, Vasoactive, Intestinal, Peptide, Receptors, VPAC, VIP, agonists, Vasoactive, Intestinal, Peptide, (guinea, pig), VIP, Receptors, VIP, Receptors, Tocris Bioscience
