Biological Activity
Reversed amino acid sequence control peptide for SLIGKV-NH2 (Cat. No. 3010), a protease-activated receptor 2 (PAR2) agonist.
Technical Data
| M. Wt | 614.79 |
| Formula | C28H54N8O7 |
| Sequence |
VKGILS (Modifications: Ser-6 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 942413-05-0 |
| PubChem ID | 90488839 |
| InChI Key | IYJUKRSADJIIBX-WAUHAFJUSA-N |
| Smiles | [H]N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 2 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 614.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.63 mL | 8.13 mL | 16.27 mL |
| 5 mM | 0.33 mL | 1.63 mL | 3.25 mL |
| 10 mM | 0.16 mL | 0.81 mL | 1.63 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.33 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Tognetto et al (2000) Evidence that PAR-1 and PAR-2 mediate prostanoid-dependent contraction in isolated guinea-pig gallbladder. Br.J.Pharmacol. 131 689 PMID: 11030717
Huang (2007) Protease-activated receptor-1 (PAR1) and PAR2 but not PAR4 mediate relaxations in lower esophageal sphincter. Regul.Pept. 142 37 PMID: 17335921
Lin et al (2008) Protease-activated receptor-2 (PAR-2) is a weak enhancer of mucin secretion by human bronchial epithelial cells in vitro. Int.J.Biochem.Cell Biol. 40 1379 PMID: 18077203
Keywords: VKGILS-NH2, supplier, Control, peptide, SLIGKV-NH2, PAR, Receptors, Protease-Activated, proteinase-activated, Protease-Activated, Receptors, Protease-Activated, Receptors, Tocris Bioscience
