BiologicalActivity
PotentinhibitorofPTEN(phosphataseandtensinhomolog)(IC50=35nM).DisplaysselectivityforPTENovercysteine-basedphosphatasessuchasSopB,MTM,PTPβandSAC(IC50valuesare588nM,4.03,57.5and>10μMrespectively).IncreasesPIP2andPIP3levels;alsoincreasesAkttranslocationinNIH/3T3fibroblasts.BlockstheimmunosuppressantactivityofIDO-activatedTregs.Promotesantitumorinflammatoryresponseincombinationwithimmunotherapyandenhancesanticancerchemotherapyintumor-bearingmice.
TechnicalData
| M.Wt | 361.16 |
| Formula | C12H10N2O8V |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 675848-25-6 |
| PubChemID | 90488861 |
| InChIKey | DUQTXODYOYERFR-UHFFFAOYSA-N |
| Smiles | [O-][V]=O.OC(=O)C1=C(O)C=CC=N1.OC(=O)C1=C(O)C=CC=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.12 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight361.16.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.77mL | 13.84mL | 27.69mL |
| 5mM | 0.55mL | 2.77mL | 5.54mL |
| 10mM | 0.28mL | 1.38mL | 2.77mL |
| 50mM | 0.06mL | 0.28mL | 0.55mL |
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