Biological Activity
Sphingosine-1-phosphate receptor antagonist; inhibits S1P1 and S1P3 receptors (pKi values are 7.86 and 5.93 respectively).
Technical Data
| M. Wt | 372.4 |
| Formula | C17H29N2O5P |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 449173-19-7 |
| PubChem ID | 11588811 |
| InChI Key | MRUSUGVVWGNKFE-MRXNPFEDSA-N |
| Smiles | O=C([C@H](N)COP(O)(O)=O)NC1=CC(CCCCCCCC)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 2eq. NaOH | 18.62 | 50 | |
| Acidified DMSO (5% 1N HCl in DMSO) | 3.72 | 10mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 372.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.69 mL | 13.43 mL | 26.85 mL |
| 5 mM | 0.54 mL | 2.69 mL | 5.37 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.69 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Davis et al (2005) Sphingosine-1-phosphate analogs as receptor antagonists. J.Biol.Chem. 280 9833 PMID: 15590668
Aoki et al (2007) The suppressive effect of sphingosine-1-phosphate on monocyte-endothelium adhesion may be mediated by the rearrangement of the endothelial integrins α5β1 and αVβ3. J.Thromb.Haemost. 5 1292 PMID: 17403093
Mihovilovic et al (2007) High-fat/cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL. J.Lipid Res. 48 806 PMID: 17264352
Keywords: VPC 23019, supplier, VPC23019, sphingosine-1-phosphate, s1p1, s1p3, antagonists, s1p, sphingolipids, Sphingosine-1-phosphate, Receptors, Sphingosine-1-phosphate, Receptors, Tocris Bioscience
