Biological Activity
Potent and selective phospholipase D1 (PLD1) inhibitor (IC50 values are 46 and 933 nM for PLD1 and PLD2 respectively). Inhibits migration of human and mouse breast cancer cell lines in transwell assays.
Compound Libraries
VU 0155069 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 499.43 |
| Formula | C26H27ClN4O2.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1130067-06-9 |
| PubChem ID | 56972237 |
| InChI Key | RQULTQQAHGYYDG-LMOVPXPDSA-N |
| Smiles | O=C(N[C@@H](C)CN3CCC(N5C4=C(NC5=O)C=C(Cl)C=C4)CC3)C(C=C2)=CC1=C2C=CC=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.94 | 100 | |
| ethanol | 24.97 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 499.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2 mL | 10.01 mL | 20.02 mL |
| 5 mM | 0.4 mL | 2 mL | 4 mL |
| 10 mM | 0.2 mL | 1 mL | 2 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Scott et al (2009) Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat.Chem.Biol. 5 108 PMID: 19136975
Lewis et al (2009) Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg.Med.Chem.Lett. 19 1916 PMID: 19268584
Keywords: VU 0155069, supplier, VU0155069, PLD1, phospholipases, D, specific, inhibitors, inhibits, potent, selective, esterases, Phospholipases, Phospholipases, Tocris Bioscience
