Biological Activity
Potent ACKR3 (CXCR7) chemokine receptor agonist (EC50 = 1.6 nM). Induces recruitment of β-arrestin to CXCR7 in HEK293-CXCR7 cells.
Compound Libraries
VUF 11207 fumarate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 586.65 |
| Formula | C27H35FN2O4.C4H4O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 90488970 |
| InChI Key | MTPOECCHJLVVGO-FDULSSLPSA-N |
| Smiles | CC(CN(CCC2N(C)CCC2)C(C3=CC(OC)=C(OC)C(OC)=C3)=O)=C/C1=C(F)C=CC=C1.OC(/C=C/C(O)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 58.66 | 100 | |
| water | 58.66 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 586.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.7 mL | 8.52 mL | 17.05 mL |
| 5 mM | 0.34 mL | 1.7 mL | 3.41 mL |
| 10 mM | 0.17 mL | 0.85 mL | 1.7 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Wijtmans et al (2012) Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists. Eur.J.Med.Chem. 51 184 PMID: 22424612
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