Biological Activity
Potent histamine H3 receptor silent antagonist (pKi = 8.35).
Technical Data
| M. Wt | 355.11 |
| Formula | C11H19N3.2HBr |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 639089-06-8 |
| PubChem ID | 53440140 |
| InChI Key | YFFVIGXPKWSZHW-UHFFFAOYSA-N |
| Smiles | Br.Br.C(CC1CCNCC1)CC1=CNC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.51 | 100 | |
| water | 35.51 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 355.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.82 mL | 14.08 mL | 28.16 mL |
| 5 mM | 0.56 mL | 2.82 mL | 5.63 mL |
| 10 mM | 0.28 mL | 1.41 mL | 2.82 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Kitbunnadaj et al (2004) Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H3 receptor agonist. J.Med.Chem. 47 2414 PMID: 15115383
Leurs et al (2005) The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat.Rev.Drug Discov. 4 107 PMID: 15665857
Moreno-Delgado et al (2006) Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology 51 517 PMID: 16769092
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