Biological Activity
Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor. Decreases cholesterol levels in the plasma and liver of diabetic-hypercholesterolemic rats.
Technical Data
| M. Wt | 449.57 |
| Formula | C25H27N3O3S |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 228544-65-8 |
| PubChem ID | 9933427 |
| InChI Key | XFFITGBWVLQNCD-UHFFFAOYSA-N |
| Smiles | O=C(NC3=C(C(C)C)C=CC=C3C(C)C)NC(C=C2)=CC=C2SC1=CC=C([N+]([O-])=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.96 | 100 | |
| ethanol | 2.25 | 5 |
Preparing Stock Solutions
The following data is based on the product molecular weight 449.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.22 mL | 11.12 mL | 22.24 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.45 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.22 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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References
References are publications that support the products' biological activity.
Adameova et al (2006) Protective effect of simvastatin and VULM 1457 in ischaemic-reperfused myocardium of the diabetic-hypercholesterolemic rats. Pharmazie 61 807 PMID: 17020164
Adameova
et al (2007) The myocardial infarct size-limiting and antiarrhythmic effects of acyl-CoA: cholesterol acyltransferase inhibitor VULM 1457 protect the hearts of diabetic-hypercholesterolaemic rats against ischaemia/reperfusion injury both in vitro and in v Eur.J.Pharmacol. 576 114 PMID: 17764671
Vojtassakova
et al (2007) Effect of VULM 1457, an ACAT inhibitor, on serum lipid levels and on real time red blood cell flow in diabetic and non-diabetic hamsters fed high cholesterol-lipid diet. Gen.Physiol.Biophys. 26 254 PMID: 18281742
Keywords: VULM 1457, supplier, Acyl-CoA, cholesterol, acyltransferase, ACAT, inhibitors, inhibits, Transferases, VULM1457, Acyl-CoA:Cholesterol, Acyltransferase, Acyl-CoA:Cholesterol, Acyltransferase, Tocris Bioscience
