Biological Activity
Histone deacetylase inhibitor (IC50 = 400 μM) that exhibits anticancer, anti-inflammatory and neuroprotective effects. Displays anticonvulsive activity via an increase in GABA levels and decreases Aβ production in animal models of Alzheimer's disease. Also attenuates NMDA-mediated excitation, blocks voltage-gated Na+ channels and modulates firing of neurons. Enables induction of pluripotent stem cells from somatic cells by Oct4 and Sox2. Can induce autophagy by inhibiting inositol synthesis.
Compound Libraries
Valproic acid, sodium salt is also offered as part of the Tocriscreen Plus, Tocriscreen Epigenetics Toolbox and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 166.19 |
| Formula | C8H15NaO2 |
| Storage | Desiccate at RT |
| CAS Number | 1069-66-5 |
| PubChem ID | 16760703 |
| InChI Key | AEQFSUDEHCCHBT-UHFFFAOYSA-M |
| Smiles | [Na+].CCCC(CCC)C([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.31 | 50 | |
| water | 16.62 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 166.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.02 mL | 30.09 mL | 60.17 mL |
| 5 mM | 1.2 mL | 6.02 mL | 12.03 mL |
| 10 mM | 0.6 mL | 3.01 mL | 6.02 mL |
| 50 mM | 0.12 mL | 0.6 mL | 1.2 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Phiel et al (2001) Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J.Biol.Chem. 276 36734 PMID: 11473107
Kostrouchova et al (2007) Valproic acid, a molecular lead to multiple regulatory pathways. Folia Biologica 53 37 PMID: 17448293
Kim et al (2007) Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J.Pharmacol.Exp.Ther. 321 892 PMID: 17371805
Qing et al (2008) Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioural defects in Alzheimer's disease mouse models. J.Exp.Med. 205 2781 PMID: 18955571
Huangfu et al (2008) Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat.Biotechnol. 26 1269 PMID: 18849973
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