Biological Activity
High affinity AT1 receptor antagonist (Ki = 2.38 nM). Displays 30,000-fold selectivity over AT2 receptors. Inhibits angiotensin II-induced release of aldosterone in vitro. Orally active.
Compound Libraries
Valsartan is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 435.52 |
| Formula | C24H29N5O3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 137862-53-4 |
| PubChem ID | 60846 |
| InChI Key | ACWBQPMHZXGDFX-QFIPXVFZSA-N |
| Smiles | CC(C)[C@@H]([C@@](O)=O)N(C(CCCC)=O)CC(C=C3)=CC=C3C1=CC=CC=C1C2=NN=NN2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.55 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 435.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.3 mL | 11.48 mL | 22.96 mL |
| 5 mM | 0.46 mL | 2.3 mL | 4.59 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Criscione et al (1993) Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype. Br.J.Pharmacol. 110 761 PMID: 8242249
Wexler et al (1996) Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. J.Med.Chem. 39 625 PMID: 8576904
Hanafy et al (2008) Effects of angiotensin II blockade on inflammation-induced alterations of pharmacokinetics and pharmacodynamics of calcium channel blockers. Br.J.Pharmacol. 153 90 PMID: 17965735
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