Biological Activity
Voltage-gated Na+ channel opener; increases intracellular Ca2+ with no effect on the Na+/Ca2+ exchanger. Steroid-derived alkaloid neurotoxin. Increases membrane Na+ permeability and depolarizes excitable tissues.
Technical Data
| M. Wt | 673.79 |
| Formula | C36H51NO11 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 71-62-5 |
| PubChem ID | 6280 |
| InChI Key | FVECELJHCSPHKY-YFUMOZOISA-N |
| Smiles | O=C(C8=CC=C(OC)C(OC)=C8)O[C@H]1CC[C@@]2(C)[C@@]3([H])[C@@](O)1O[C@@]42[C@@]([C@@](C[C@H](O)[C@@]6(O)[C@]([H])5CN7[C@](CC[C@H](C)C7)([H])[C@@](O)6C)(O)[C@@]5(O)C4)([H])CC3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.69 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 673.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.48 mL | 7.42 mL | 14.84 mL |
| 5 mM | 0.3 mL | 1.48 mL | 2.97 mL |
| 10 mM | 0.15 mL | 0.74 mL | 1.48 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.3 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
McKinney et al (1986) Purification, solubility and pKa of veratridine. Anal.Biochem. 153 33 PMID: 3963380
Maroto et al (1994) Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+ oscillations induced by veratridine. Eur.J.Pharmacol. 270 331 PMID: 7805782
Fekete et al (2009) Mechanism of the persistant sodium current activator veratridine-evoked Ca2+ elevation: implication for epilepsy. J.Neurochem. 111 745 PMID: 19719824
Keywords: Veratridine, supplier, Sodium, channel, opener, neutoxin, Na+, Na, voltage-gated, ion, channels, neurotoxins, Voltage-gated, Sodium, Channels, Voltage-gated, Sodium, Channels, Tocris Bioscience
