Biological Activity
Inhibitor of acetylcholine transport (Ki = 2 nM). Centrally active following systemic administration in vivo.
Compound Libraries
(±)-Vesamicol hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 295.85 |
| Formula | C17H25NO.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 120447-62-3 |
| PubChem ID | 659839 |
| InChI Key | XJNUHVMJVWOYCW-GBNZRNLASA-N |
| Smiles | O[C@@H]1CCCC[C@H]1N(CC3)CCC3C2=CC=CC=C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.79 | 50mM with gentle warming | |
| ethanol | 5.92 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 295.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.38 mL | 16.9 mL | 33.8 mL |
| 5 mM | 0.68 mL | 3.38 mL | 6.76 mL |
| 10 mM | 0.34 mL | 1.69 mL | 3.38 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Efange et al (1997) N-hydroxyalkyl derivatives of 3β-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters. J.Med.Chem. 40 3905 PMID: 9397171
Kobayashi et al (1997) Effects of systemic administration of 2-(4-phenyl-piperidino)-cyclohexanol (vesamicol) and an organophosphate DDVP on the cholinergic system in brain regions of rats. Brain Res.Bull. 43 17 PMID: 9205789
Varoqui and Erickson (1996) Active transport of acetylcholine by the human vesicular acetylcholine transporter. J.Biol.Chem. 271 27229 PMID: 8910293
Keywords: (±)-Vesamicol hydrochloride, supplier, AH5183, inhibitors, inhibits, ACh, transport, Acetylcholine, Transporters, Monoamine, Neurotransmitter, AH, 5183, Acetylcholine, Transporters, Acetylcholine, Transporters, Tocris Bioscience
