Biological Activity
Selective GABA-T (transaminase) inhibitor. Anticonvulsant.
Technical Data
| M. Wt | 129.16 |
| Formula | C6H11NO2 |
| Storage | Desiccate at +4°C |
| Purity | ≥98% |
| CAS Number | 60643-86-9 |
| PubChem ID | 5665 |
| InChI Key | PJDFLNIOAUIZSL-UHFFFAOYSA-N |
| Smiles | NC(C=C)CCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| phosphate buffered saline | 12.92 | 100 | |
| water | 12.92 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 129.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 7.74 mL | 38.71 mL | 77.42 mL |
| 5 mM | 1.55 mL | 7.74 mL | 15.48 mL |
| 10 mM | 0.77 mL | 3.87 mL | 7.74 mL |
| 50 mM | 0.15 mL | 0.77 mL | 1.55 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Halonen et al (1991) Effects of vigabatrin (γ-vinyl GABA) on neurotransmission-related amino acids and on GABA and benzodiazepine receptor binding in rats. Epilepsia 32 242 PMID: 1672276
Larsson et al (1986) Differential effect of gamma-vinyl GABA and valproate on GABA transaminase from cultured neurones and astrocytes. Neuropharmacology 25 617 PMID: 3092125
Schmid et al (1996) Vigabatrin modulates benzodiazepine receptor activity in vivo: a positron emission tomography study in baboon. J.Pharmacol.Exp.Ther. 276 977 PMID: 8786578
Keywords: Vigabatrin, supplier, GABA-T, inhibitors, inhibits, GABA-Transferase, Transferases, GABA, GABAA, GABAC, Receptors, GABAB, (±)-γ-Vinyl, (±)-gamma-Vinyl, (±)-g-Vinyl, GABA, Miscellaneous, GABA, GABAB, Receptors, Other, Transferases, Miscellaneous, GABA, Tocris Bioscience
