Biological Activity
Anticancer agent; microtubule disrupter. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Shown to inhibit autophagosome maturation.
Technical Data
| M. Wt | 909.06 |
| Formula | C46H58N4O9.H2SO4 |
| Storage | Desiccate at +4°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 143-67-9 |
| PubChem ID | 241902 |
| InChI Key | KDQAABAKXDWYSZ-JKDPCDLQSA-N |
| Smiles | OS(O)(=O)=O.[H][C@@]23N(C)C1=CC(OC)=[C@]([C@@]7([C@](OC)=O)C[C@H]6C[C@@](O)(CC)CN(CCC8=C7NC9=C8C=CC=C9)C6)C=C1[C@@]52[C@](N(CC5)CC=C4)([H])[C@]4(CC)[C@@H](OC(C)=O)[C@]([C@](OC)=O)3O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 90.91 | 100 | |
| water | 90.91 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 909.06. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.1 mL | 5.5 mL | 11 mL |
| 5 mM | 0.22 mL | 1.1 mL | 2.2 mL |
| 10 mM | 0.11 mL | 0.55 mL | 1.1 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.22 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Jordan et al (1985) Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 45 2741 PMID: 3986806
Rai and Wolf (1998) Localization of critical histidyl residues required for vinblastine-induced tubulin polymerization and for microtubulin assembly. J.Biol.Chem. 273 31131 PMID: 9813016
Tsukidate et al (1993) Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes. Am.J.Pathol. 143 918 PMID: 8362985
Veldhoen et al (2012) The chemotherapeutic agent paclitaxel inhibits autophagy through two distinct mechanisms that regulate apoptosis. Oncogene 32 736 PMID: 22430212
Keywords: Vinblastine sulfate, supplier, Disrupts, microtubules, Mitosis, Tau, Tubulin, chemotherapeutics, Microtubules, Mitosis, Autophagy, Microtubules, Tocris Bioscience
