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4000-520-616
当前位置: 首页 > 产品中心 > Other_enzymes > Tocris/XMD 8-92/4132/10/10 mg
商品详细Tocris/XMD 8-92/4132/10/10 mg
Tocris/XMD 8-92/4132/10/10 mg
Tocris/XMD 8-92/4132/10/10 mg
商品编号: 4132/10
品牌: Tocris Bioscience
市场价: ¥4500.00
美元价: 2700.00
产地: 美国(厂家直采)
公司:
产品分类: 其它酶
公司分类: Other_enzymes
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description:ERK5/BMK1inhibitor;alsoBRD4inhibitor
ChemicalName:2-[[2-Ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

ERK5(BMK1)andBRD4inhibitor(Kdvaluesare80and190nM,respectively).AlsoinhibitsDCAMKL2,PLK4andTNK1(Kdvaluesare190,600and890nM).Blocksgrowthfactor-inducedactivationofcellularBMK1andreducesBMK1activityininvitrokinaseassays.AlsoreducesBMK1-dependenttransactivatingactivityofMEF2C.Inhibitsproliferationinavarietyofcancercelllines;blockstumorcellproliferationandtumor-associatedangiogenesis.

LicensingInformation

SoldunderlicensefromtheDana-FarberCancerInstitute.

ExternalPortalInformation

Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofXMD8-92isreviewedonthechemicalprobeswebsite.

CompoundLibraries

XMD8-92isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt474.55
FormulaC26H30N6O3
StorageStoreatRT
Purity≥98%(HPLC)
CASNumber1234480-50-2
PubChemID46843772
InChIKeyQAPAJIZPZGWAND-UHFFFAOYSA-N
SmilesO=C2C3=C(C=CC=C3)N(C)C1=NC(NC4=C(OCC)C=C(N5CCC(O)CC5)C=C4)=NC=C1N2C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO18.9840

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight474.55.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.11mL10.54mL21.07mL
5mM0.42mL2.11mL4.21mL
10mM0.21mL1.05mL2.11mL
50mM0.04mL0.21mL0.42mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet