Biological Activity
β1-adrenoceptor-selective partial agonist (pA2 values are 7.4 - 7.8 and 5.2 - 6.2 at β1- and β2-adrenoceptors respectively).
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Compound Libraries
Xamoterol hemifumarate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 397.43 |
| Formula | C16H25N3O5.0.5C4H4O4 |
| Storage | Store at RT |
| Purity | ≥97% (HPLC) |
| CAS Number | 73210-73-8 |
| PubChem ID | 6440459 |
| InChI Key | QEDVGROSOZBGOZ-WXXKFALUSA-N |
| Smiles | [H]OC(=O)C=CC(=O)O[H].OC(CNCCNC(=O)N1CCOCC1)COC1=CC=C(O)C=C1.OC(CNCCNC(=O)N1CCOCC1)COC1=CC=C(O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.74 | 100 | |
| water | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 397.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.52 mL | 12.58 mL | 25.16 mL |
| 5 mM | 0.5 mL | 2.52 mL | 5.03 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.52 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Barlow et al (1981) β-Adrenoceptor stimulant properties of aminoalkylamino-substituted 1-aryl-2-ethanols and 1-(aryloxy)-2-propanols. J.Med.Chem. 24 315 PMID: 6115058
Malta et al (1985) The in vitro pharmacology of xamoterol (ICI 118,587). Br.J.Pharmacol. 85 179 PMID: 2862938
Nuttall and Snow (1982) The cardiovascular effects of ICI 118,587: a β1-adrenoceptor partial agonist. Br.J.Pharmacol. 77 381 PMID: 6128041
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