Biological Activity
Shown to selectively activate group II mGlu receptors in transfected HEK293 cells at nanomolar concentrations. Attenuates cAMP formation in mouse cortical slices expressing mGlu2 and mGlu3 receptors.
Technical Data
| M. Wt | 205.17 |
| Formula | C10H7NO4 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 59-00-7 |
| PubChem ID | 5699 |
| InChI Key | FBZONXHGGPHHIY-UHFFFAOYSA-N |
| Smiles | OC1=C2C(C(O)=CC(C(O)=O)=N2)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.52 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 205.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.87 mL | 24.37 mL | 48.74 mL |
| 5 mM | 0.97 mL | 4.87 mL | 9.75 mL |
| 10 mM | 0.49 mL | 2.44 mL | 4.87 mL |
| 50 mM | 0.1 mL | 0.49 mL | 0.97 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Han et al (2007) The tryptophan oxidation pathway in mosquitoes with emphasis on xanthurenic acid biosynthesis. J.Insect.Physiol. 53 254 PMID: 17070835
Mauro et al (2010) Xanthurenic acid, a novel endogenous ligand for metabotropic glutamate receptors. Program No. 643.1/F2. 2010 Neuroscience Meeting Pl 2010 (Online) PMID:
Keywords: Xanthurenic acid, supplier, metabotropic, glutamate, receptors, mGlu, ligands, group, II, 2, mglu2, mglu3, Glutamate, (Metabotropic), Group, II, Receptors, Glutamate, (Metabotropic), Group, II, Receptors, Tocris Bioscience
