Biological Activity
Calmodulin antagonist (inhibits Ca2+-calmodulin dependent PDE with an IC50 of 240 μM).
Technical Data
| M. Wt | 342.88 |
| Formula | C16H22N2O2S.HCl |
| Storage | Store at RT |
| CAS Number | 61714-25-8 |
| PubChem ID | 173829 |
| InChI Key | HOCSVIGHWPLMFC-UHFFFAOYSA-N |
| Smiles | Cl.NCCCCCCNS(=O)(=O)C1=C2C=CC=CC2=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.14 | 50 | |
| water | 3.43 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 342.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.92 mL | 14.58 mL | 29.16 mL |
| 5 mM | 0.58 mL | 2.92 mL | 5.83 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.92 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Hidaka et al (1981) Activity-structure relationship of calmodulin antagonists. Naphthalenesulfonamide derivatives. Mol.Pharmacol. 20 571 PMID: 7329399
Hidaka et al (1981) N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc.Natl.Acad.Sci.U.S.A. 78 4354 PMID: 6945588
Hidaka and Tanaka (1983) Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 102 185 PMID: 6139736
Keywords: W-5 hydrochloride, supplier, Calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, Calcium, Binding, Protein, Calcium, Binding, Protein, Tocris Bioscience
