Biological Activity
Potent and selective inhibitor of MMP-13 (IC50 values are 17, 945, > 1000 and > 10000 nM for MMP-13, MMP-9, TACE and MMP-1 respectively).
Compound Libraries
WAY 170523 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 613.68 |
| Formula | C33H31N3O7S |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 307002-73-9 |
| PubChem ID | 9830392 |
| InChI Key | FARMEEAGJWMFSZ-UHFFFAOYSA-N |
| Smiles | CC1=CC(C(=O)NO)=C(N(CC2=CC=CC=C2)S(=O)(=O)C2=CC=C(OCCNC(=O)C3=CC4=CC=CC=C4O3)C=C2)C(C)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 61.37 | 100 | |
| ethanol | 61.37 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 613.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.63 mL | 8.15 mL | 16.3 mL |
| 5 mM | 0.33 mL | 1.63 mL | 3.26 mL |
| 10 mM | 0.16 mL | 0.81 mL | 1.63 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.33 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Chen et al (2000) Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. J.Am.Chem.Soc. 122 9648 PMID:
Jaffré et al (2012) beta -adrenergic receptor stimulation transactivates protease-activated receptor 1 via matrix metalloproteinase 13 in cardiac cells. Circulation 125 2993 PMID: 22610965
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