Biological Activity
Selective ERβ receptor agonist that displays 68-fold selectivity over ERα (EC50 values are 2 and 155 nM for ERβ and ERα respectively). Displays antianxiolytic and antidepressive effects in vivo.
Compound Libraries
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Technical Data
| M. Wt | 306.11 |
| Formula | C13H8BrNO3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 440122-66-7 |
| PubChem ID | 9861330 |
| InChI Key | IVFWABSHZFOMIG-UHFFFAOYSA-N |
| Smiles | BrC1=C2C(N=C(C3=CC=C(O)C=C3)O2)=CC(O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.61 | 100 | |
| ethanol | 15.31 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 306.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.27 mL | 16.33 mL | 32.67 mL |
| 5 mM | 0.65 mL | 3.27 mL | 6.53 mL |
| 10 mM | 0.33 mL | 1.63 mL | 3.27 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.65 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Malamas et al (2004) Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands. J.Med.Chem. 47 5021 PMID: 15456246
Hughes et al (2008) WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent. Neuropharmacology 54 1136 PMID: 18423777
Clipperton et al (2008) Differential effects of estrogen receptor alpha and beta specific agonists on social learning of food preferences in female mice. Neuropsychopharmacology 33 2362 PMID: 18004284
Keywords: WAY 200070, supplier, Selective, ERβ, ERbeta, agonists, estrogen, receptors, WAY200070, Estrogen, and, Related, Receptors, Estrogen, and, Related, Receptors, Tocris Bioscience
