Biological Activity
Gonadotropin releasing hormone receptor (GnRH-R) antagonist. Exhibits potent affinity (IC50 values are 12 and 71 nM for human and rat GnRH receptors respectively). Lowers plasma leuteinizing hormone levels in the rat. Orally active.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries
WAY 207024 dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 549.54 |
| Formula | C30H32N6.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 872002-73-8 |
| PubChem ID | 69403574 |
| InChI Key | REQCNTGYEABOIT-UHFFFAOYSA-N |
| Smiles | CC(C)(C)C(C=C6)=CC=C6C(N5)=NC1=C5C(N(CC4)CCN4CC2=CC=C(N=CC=N3)C3=C2)=CC=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.71 | 85 |
Preparing Stock Solutions
The following data is based on the product molecular weight 549.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.82 mL | 9.1 mL | 18.2 mL |
| 5 mM | 0.36 mL | 1.82 mL | 3.64 mL |
| 10 mM | 0.18 mL | 0.91 mL | 1.82 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Pelletier et al (2009) Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). J.Med.Chem. 52 214 PMID: 19072222
Keywords: WAY 207024 dihydrochloride, supplier, WAY207024, dihydrochloride, GnRH, antagonists, gonadtrophin, releasing, hormone, antagonist, gonadotropin, Gonadotrophin-Releasing, Hormone, Receptors, Gonadotrophin-Releasing, Hormone, Receptors, Tocris Bioscience
