Biological Activity
Selective 5-HT2C agonist. Ki values are 56, 2350, 1575 and 815 nM for human recombinant 5-HT2C, 5-HT2A, 5-HT6 and 5-HT7 receptors respectively. Stimulates intracellular Ca2+ mobilization in CHO cells expressing human 5-HT2C receptors (EC50 = 72 nM). Reduces food intake in rats.
Technical Data
| M. Wt | 262.78 |
| Formula | C15H18N2.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 57756-44-2 |
| PubChem ID | 12259556 |
| InChI Key | PZXUJERSOFOWES-UHFFFAOYSA-N |
| Smiles | Cl.C1CCC2=C(C1)N1CCNCC3=C1C2=CC=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.28 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 262.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.81 mL | 19.03 mL | 38.05 mL |
| 5 mM | 0.76 mL | 3.81 mL | 7.61 mL |
| 10 mM | 0.38 mL | 1.9 mL | 3.81 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.76 mL |
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References
References are publications that support the products' biological activity.
Sabb et al (2004) Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor. Bioorg.Med.Chem.Lett. 14 2603 PMID: 15109661
Dunlop et al (2004) Identification of cycloalkyl[b][1,4]benzodiazepinoindoles as novel 5-HT2C receptor agonists. Fund.Clin.Pharmacol. 18 145 PMID:
Keywords: WAY 629 hydrochloride, supplier, Selective, 5-HT2C, agonists, Serotonin, Receptors, WAY629, hydrochloride, 5-HT2C, Receptors, 5-HT2C, Receptors, Tocris Bioscience
