Biological Activity
α1A-adrenergic selective antagonist. Also available as part of the α1-Adrenoceptor Tocriset™.
Technical Data
| M. Wt | 381.86 |
| Formula | C19H23NO5.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 2170-58-3 |
| PubChem ID | 11957505 |
| InChI Key | KAHMEWANVDFFCQ-UHFFFAOYSA-N |
| Smiles | Cl.COC1=CC=CC(OC)=C1OCCNCC1COC2=C(O1)C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 19.09 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 381.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.62 mL | 13.09 mL | 26.19 mL |
| 5 mM | 0.52 mL | 2.62 mL | 5.24 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.62 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Green et al (1969) The synthesis and pharmacological properties of a series of 2-substituted aminomethyl-1,4-benzodioxanes. J.Med.Chem. 12 326 PMID: 5791620
Heible et al (1995) α and β-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 38 3415 PMID: 7658428
Morrow and Creese (1986) Characterisation of α1-adrenergic receptor subtypes in rat brain: a re-evaluation of 3H-WB 4101 and 3H-prazosin binding. Mol.Pharmacol. 29 321 PMID: 3010073
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