BiologicalActivity
JAK3inhibitor(IC50=1.8μM)thatdisplaysnoactivityatJAK1orJAK2.InhibitsSTAT1activation,iNOSexpressionandNOproductioninmacrophagesinvitro.AlsoinhibitsothercommonkinasesincludingEGFR(IC50=4nM),Src,Abl,VEGFR,MAPKandPI3-Kandinducesapoptosisinhumanglioblastomacelllines(IC50=158μM).InducesdifferentiationofneuralProgenitorcells.
CompoundLibraries
WHI-P154isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 376.2 |
| Formula | C16H14BrN3O3 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 211555-04-3 |
| PubChemID | 3795 |
| InChIKey | CBIAKDAYHRWZCU-UHFFFAOYSA-N |
| Smiles | OC(C=C3)=C(Br)C=C3NC2=NC=NC1=CC(OC)=C(OC)C=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.62 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight376.2.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.66mL | 13.29mL | 26.58mL |
| 5mM | 0.53mL | 2.66mL | 5.32mL |
| 10mM | 0.27mL | 1.33mL | 2.66mL |
| 50mM | 0.05mL | 0.27mL | 0.53mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
本网站将在规定时间内给予删除等相关处理。
