Biological Activity
Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) (IC50 = 0.3 μM). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis.
Technical Data
| M. Wt | 366.11 |
| Formula | C12H20Cl4N2O2 |
| Storage | Store at +4°C |
| CAS Number | 1477-57-2 |
| PubChem ID | 15134 |
| InChI Key | FAOMZVDZARKPFJ-UHFFFAOYSA-N |
| Smiles | ClC(Cl)C(NCCCCCCCCNC(C(Cl)Cl)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.61 | 100 | |
| ethanol | 7.32 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 366.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.73 mL | 13.66 mL | 27.31 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.73 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Amory et al (2011) Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. J.Androl. 32 111 PMID: 20705791
Hogarth et al (2011) Suppression of Stra8 expression in the mouse gonad by WIN 18,446. Biol.Reprod. 84 957 PMID: 21209416
Keywords: WIN 18446, supplier, WIN18446, spermatogenesis, inhibitors, inhibits, aldehyde, dehydrogenases, ALDH1a2, Aldehyde, Dehydrogenase, Aldehyde, Dehydrogenase, Tocris Bioscience
