Biological Activity
The first potent, non-peptide, competitive bradykinin B2 receptor antagonist. In organ bath studies, WIN 64338 inhibits [3H]-bradykinin binding on guinea pig trachea with nanomolar affinity but is not active in the rabbit aorta (the classical bradykinin B1 preparation).
Compound Libraries
WIN 64338 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 783.95 |
| Formula | C45H68ClN4OP.HCl |
| Storage | Desiccate at +4°C |
| CAS Number | 163727-74-0 |
| PubChem ID | 9832172 |
| InChI Key | YYJGBEZPVOUBMJ-KRFCICRISA-N |
| Smiles | O=C(NC5=CC=C(C[P+](CCCC)(CCCC)CCCC)C=C5)[C@H](CC3=CC=C(C=CC=C4)C4=C3)NC(NC2CCCCC2)=NC1CCCCC1.Cl.[Cl-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 58.8 | 75 |
Preparing Stock Solutions
The following data is based on the product molecular weight 783.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.28 mL | 6.38 mL | 12.76 mL |
| 5 mM | 0.26 mL | 1.28 mL | 2.55 mL |
| 10 mM | 0.13 mL | 0.64 mL | 1.28 mL |
| 50 mM | 0.03 mL | 0.13 mL | 0.26 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Hu et al (2004) Action of bradykinin in the submucosal plexus of guinea pig small intestine. J.Pharmacol.Exp.Ther. 309 320 PMID: 14718600
Marceau et al (1994) Effects of peptide and nonpeptide antagonists of bradykinin B2 receptors on the venoconstrictor action of bradykinin. J.Pharmacol.Exp.Ther. 269 1136 PMID: 8014858
Scherrer et al (1995) Effects of WIN 64338, a nonpeptide bradykinin B2 receptor antagonist, on guinea-pig trachea. Br.J.Pharmacol. 115 1127 PMID: 7582533
Keywords: WIN 64338 hydrochloride, supplier, Bradykinin, B2, antagonists, Receptors, WIN64338, hydrochloride, Bradykinin, Receptors, Bradykinin, Receptors, Tocris Bioscience
