Biological Activity
Selective agonist for the formyl peptide receptors FPR2 and FPR3, expressed on immune cells. EC50 values for induction of calcium mobilization in FPR2-HL-60 cells and FPR3-HL-60 cells are 2 and 80 nM respectively.
Technical Data
| M. Wt | 856.11 |
| Formula | C41H61N9O7S2 |
| Sequence |
WKYMVM (Modifications: Met-6 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 187986-11-4 |
| PubChem ID | 68661247 |
| InChI Key | FMBGOORJEKQQLG-LXOXETEGSA-N |
| Smiles | [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 0.60 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 856.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.17 mL | 5.84 mL | 11.68 mL |
| 5 mM | 0.23 mL | 1.17 mL | 2.34 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.17 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Baek et al (1996) Identification of the peptides that stimulate the phosphoinositide hydrolysis in lymphocyte cell lines from peptide libraries. J.Biol.Chem. 271 8170 PMID: 8626507
Christophe et al (2001) The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/Lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J.Biol.Chem. 276 21585 PMID: 11285256
Christophe et al (2002) Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1 /LXA4R, is not affected by lipoxin. Scand.J.Immunol. 56 470 PMID: 12410796
Keywords: WKYMVM, supplier, Selective, FPR2, FPR3, receptor, agonists, FPRL, Formyl, like, Peptide, Receptors, W-peptide, Formyl, Peptide, Receptors, Formyl, Peptide, Receptors, Tocris Bioscience
