Biological Activity
Potent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM).
Technical Data
| M. Wt | 289.41 |
| Formula | C18H27NO2 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 68489-09-8 |
| PubChem ID | 11266244 |
| InChI Key | HNSGVPAAXJJOPQ-XOKHGSTOSA-N |
| Smiles | C[C@H](C)[C@H]1[C@H]([C@@](NC2=CC=C(OC)C=C2)=O)C[C@H](C)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 21.71 | 75 |
Preparing Stock Solutions
The following data is based on the product molecular weight 289.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.46 mL | 17.28 mL | 34.55 mL |
| 5 mM | 0.69 mL | 3.46 mL | 6.91 mL |
| 10 mM | 0.35 mL | 1.73 mL | 3.46 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.69 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Beck et al (2007) Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators. Cell Calcium 41 285 PMID: 16949669
Bodding et al (2007) Characterisation of TRPM8 as a pharmacophore receptor. Cell Calcium 42 618 PMID: 17517434
Keywords: WS 12, supplier, TRPM8, agonists, cooling, agent, Channels, Transient, Receptor, Potential, WS12, TRPM, TRPM, Tocris Bioscience
