Biological Activity
Cooling agent that is an agonist at TRPM8 receptors (EC50 = 3.7 μM).
Technical Data
| M. Wt | 211.34 |
| Formula | C13H25NO |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 39711-79-0 |
| PubChem ID | 62907 |
| InChI Key | VUNOFAIHSALQQH-UHFFFAOYSA-N |
| Smiles | CC1CC(C(NCC)=O)C(C(C)C)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.13 | 100 | |
| ethanol | 21.13 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 211.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.73 mL | 23.66 mL | 47.32 mL |
| 5 mM | 0.95 mL | 4.73 mL | 9.46 mL |
| 10 mM | 0.47 mL | 2.37 mL | 4.73 mL |
| 50 mM | 0.09 mL | 0.47 mL | 0.95 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Behrendt et al (2004) Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br.J.Pharmacol. 141 737 PMID: 14757700
Bodding (2007) TRP proteins and cancer. Cell Signal. 19 617 PMID: 17029734
Rovner (2007) Better than mint. C&EN 85 95 PMID:
Keywords: WS 3, supplier, TRPM8, agonists, cooling, agent, Channels, Transient, Receptor, Potential, WS3, TRPM, TRPM, Tocris Bioscience
