Biological Activity
α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 0.43 μM). Blocks PTZ-induced seizures in healthy mice and spontaneous seizures in R6/2 mice. Antiepileptic activity is independent of CB1 and CB2 receptors, but is GABAA receptor dependent. Brain penetrant.
Other Information
There appears to be some confusion about the structure of WWL 123. Tocris sells N-[[1,1'-Biphenyl]-3-ylmethyl)-N-methylcarbamic acid 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester [1338574-83-6], which has been confirmed by the inventor, Prof B. Cravatt, as the correct compound. Other vendors sell the corresponding 3-yl regioisomer [1338575-41-9], which is the incorrect compound.
Compound Libraries
WWL 123 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 436.5 |
| Formula | C28H24N2O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1338574-83-6 |
| PubChem ID | 90209976 |
| InChI Key | UUJGYRHAOHORFC-UHFFFAOYSA-N |
| Smiles | NC(C1=CC=C(C2=CC=C(OC(N(C)CC3=CC(C4=CC=CC=C4)=CC=C3)=O)C=C2)C=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.65 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 436.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.29 mL | 11.45 mL | 22.91 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.58 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.29 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Naydenov et al (2014) ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice. Neuron 83 361 PMID: 25033180
Keywords: WWL 123, supplier, WWL123, epilepsy, antiepileptics, anticonvulsants, alpha, beta, hydrolase, domain, 6, ABHD6, GABAA, α, β, ahydrolase, alphahydrolase, inhibits, inhibitors, Other, Hydrolases, Other, Hydrolases, Tocris Bioscience
