Biological Activity
Potent inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50 = 70 nM), an enzyme which catalyzes the hydrolysis of 2-arachidonylglycerol (Cat. No. 1298).
Technical Data
| M. Wt | 437.49 |
| Formula | C27H23N3O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 947669-91-2 |
| PubChem ID | 17759121 |
| InChI Key | QTWNORFUQILKJL-UHFFFAOYSA-N |
| Smiles | O=C(N(C)CC2=CC(C4=CC=NC=C4)=CC=C2)OC1=CC=C(C3=CC=C(C(N)=O)C=C3)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.37 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 437.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.29 mL | 11.43 mL | 22.86 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.57 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.29 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Blankman et al (2007) A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonylglycerol. Chem.Biol. 14 1347 PMID: 18096503
Li et al (2007) A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. J.Am.Chem.Soc. 129 9594 PMID: 17629278
Keywords: WWL 70, supplier, WWL70, potent, ABHD6, inhibitors, αβ-hydrolase, domain, 6, alphabeta-hydrolase, endocannabinoids, 2-arachidonylglycerol, hydrolysis, inhibits, Other, Hydrolases, Other, Cannabinoids, Other, Hydrolases, Tocris Bioscience
