Biological Activity
Selective PPARα agonist (EC50 values are 0.63, 32 and > 100 μM at PPARα, PPARγ and PPARδ respectively). Negatively inhibits NF-κB transcriptional activity and decreases the inflammatory response in vitro and in vivo.
Compound Libraries
WY 14643 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 323.8 |
| Formula | C14H14ClN3O2S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 50892-23-4 |
| PubChem ID | 5694 |
| InChI Key | SZRPDCCEHVWOJX-UHFFFAOYSA-N |
| Smiles | CC1=C(C)C(NC2=CC(Cl)=NC(SCC(O)=O)=N2)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.38 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 323.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.09 mL | 15.44 mL | 30.88 mL |
| 5 mM | 0.62 mL | 3.09 mL | 6.18 mL |
| 10 mM | 0.31 mL | 1.54 mL | 3.09 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Bishop-Bailey (2000) Peroxisome proliferator-activated receptors in the cardiovascular system. Br.J.Pharmacol. 129 823 PMID: 10696077
Forman et al (1997) Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc.Natl.Acad.Sci.U.S.A. 94 4312 PMID: 9113986
Willson et al (2000) The PPARs: from orphan receptors to drug discovery. J.Med.Chem. 43 527 PMID: 10691680
Keywords: WY 14643, supplier, Selective, PPARα, PPARalpha, agonists, Peroxisome-Proliferator, Receptors, PPARs, WY14643, PPARalpha, Receptors, PPARalpha, Receptors, Tocris Bioscience
