BiologicalActivity
PotentandselectiveNUAK1/2inhibitor(IC50valuesare20and100nMrespectively).Exhibitsnosignificantinhibitionagainstapanelof139kinases,includingtenAMPKfamilymembers.InhibitsNUAK1-mediatedMYPT1phosphorylation.AlsoinhibitscellproliferationinU2OScells.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofWZ4003isreviewedonthechemicalprobeswebsite.
TechnicalData
| M.Wt | 496.99 |
| Formula | C25H29ClN6O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1214265-58-3 |
| PubChemID | 72200024 |
| InChIKey | SDGJBAUIGHSMRI-UHFFFAOYSA-N |
| Smiles | CN(CC3)CCN3C(C=C2)=CC(OC)=C2NC1=NC=C(Cl)C(OC4=CC(NC(CC)=O)=CC=C4)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 24.85 | 50 | |
| DMSO | 9.94 | 20mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight496.99.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.01mL | 10.06mL | 20.12mL |
| 5mM | 0.4mL | 2.01mL | 4.02mL |
| 10mM | 0.2mL | 1.01mL | 2.01mL |
| 50mM | 0.04mL | 0.2mL | 0.4mL |
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ProductDatasheets
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