Biological Activity
A selective and potent 5-HT3 antagonist (Ki = 2.9 nM).
Technical Data
| M. Wt | 386.28 |
| Formula | C17H20ClN3O3.HCl |
| Storage | Desiccate at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 123040-16-4 |
| PubChem ID | 115000 |
| InChI Key | DBMKBKPJYAHLQP-UHFFFAOYSA-N |
| Smiles | Cl.CN1C(=O)COC2=C(C=C(Cl)C=C12)C(=O)NC1CN2CCC1CC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.86 | 10 | |
| water | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 386.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.59 mL | 12.94 mL | 25.89 mL |
| 5 mM | 0.52 mL | 2.59 mL | 5.18 mL |
| 10 mM | 0.26 mL | 1.29 mL | 2.59 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Fukuda et al (1991) The antiemetic profile of Y-25130, a new selective 5-HT3 receptor antagonist. Eur.J.Pharmacol. 196 299 PMID: 1654255
Haga et al (1993) The effects of orally administered Y-25130, a selective serotonin3 receptor antagonist on chemotherapeutic agent-induced emesis. Jpn.J.Pharmacol. 63 377 PMID: 8107329
Sato et al (1992) Antagonistic activity of Y-25130 on 5-HT3 receptors. Jpn.J.Pharmacol. 59 443 PMID: 1331590
Keywords: Y-25130 hydrochloride, supplier, Potent, selective, 5-HT3, antagonists, Serotonin, Receptors, 5-HT3, Receptors, 5-HT3, Receptors, Tocris Bioscience
