BiologicalActivity
Selectivep160ROCKinhibitor(Kivaluesare0.14,26,25and>250μMforp160ROCK,PKC,PKAandMLCKrespectively).AlsoinhibitsPRK2(IC50=600nM).Smoothmusclerelaxantandorallyactiveinvivo.Increasessurvivalrateofhumanembryonicstem(hES)cellsandiPSC-BMECsundergoingcryopreservation.AlsooptimizesnaïvehumanpluripotentstemcellgrowthandviABIlityfollowingnaïvecellderivationfromprimedESCsandiPSCsusingnaïvehumanstemcellmedium(NHSM).
CompoundLibraries
Y-27632dihydrochlorideisalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 320.26 |
| Formula | C14H21N3O.2HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 129830-38-2 |
| PubChemID | 14801906 |
| InChIKey | VJGZNBYDSDEOED-FJSYBICCSA-N |
| Smiles | N[C@H](C)[C@@]1([H])CC[C@H]([C@](NC2=CC=NC=C2)=O)CC1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| phosphatebufferedsaline | 32.03 | 100 | |
| water | 32.03 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight320.26.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.12mL | 15.61mL | 31.22mL |
| 5mM | 0.62mL | 3.12mL | 6.24mL |
| 10mM | 0.31mL | 1.56mL | 3.12mL |
| 50mM | 0.06mL | 0.31mL | 0.62mL |
MolarityCalculator
ReconstitutionCalculator
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ProductDatasheets
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