Biological Activity
Selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.
Technical Data
| M. Wt | 739.87 |
| Formula | C40H49N7O7 |
| Sequence |
YPGKF (Modifications: Tyr-1 = trans-Cinnamoyl-Tyr, Phe-5 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 327177-34-4 |
| PubChem ID | 11479675 |
| InChI Key | XKRAKQXQVIGYQC-PHOSSJRVSA-N |
| Smiles | NCCCC[C@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)C=CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 739.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.35 mL | 6.76 mL | 13.52 mL |
| 5 mM | 0.27 mL | 1.35 mL | 2.7 mL |
| 10 mM | 0.14 mL | 0.68 mL | 1.35 mL |
| 50 mM | 0.03 mL | 0.14 mL | 0.27 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Hollenberg et al (2004) Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br.J.Pharmacol. 143 443 PMID: 15451771
Hollenberg and Saifeddine (2001) Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides. Can.J.Physiol.Pharmacol. 79 439 PMID: 11405248
Ma et al (2001) Thrombin-induced platelet endostatin release is blocked by a proteinase activated receptor-4 (PAR4) antagonist. Br.J.Pharmacol. 134 701 PMID: 11606309
Keywords: tcY-NH2, supplier, Selective, PAR4, antagonists, Receptors, Protease-Activated, proteinase-activated, (trans-Cinnamoyl)-YPGKF-NH2, Protease-Activated, Receptors, Protease-Activated, Receptors, Tocris Bioscience
