BiologicalActivity
Nitricoxide-independentactivatorofsolubleguanylylcyclase(sGC).SignificantlyelevatescGMPlevelsandinhibitscollagen-stimulatedaggregationofwashedrabbitplatelets(IC50=14.6μM);inducesrelaxationindenudedphenylephrine-contractedrabbitaorticrings(EC50=1.9μM).AlsodisplaysantiproliferativeactivityinvitroandinvivobyinducingG1cellcyclearrestintwohumanhepatocellularcarcinoma(HCC)celllines,andinHCCxenograftsinathymicSCIDmice.Exhibitslowcytotoxicityinnon-malignantcells.
CompoundLibraries
YC1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 304.34 |
| Formula | C19H16N2O2 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 170632-47-0 |
| PubChemID | 5712 |
| InChIKey | OQQVFCKUDYMWGV-UHFFFAOYSA-N |
| Smiles | OCC4=CC=C(O4)C2=NN(CC3=CC=CC=C3)C1=CC=CC=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.43 | 100 | |
| ethanol | 15.22 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight304.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.29mL | 16.43mL | 32.86mL |
| 5mM | 0.66mL | 3.29mL | 6.57mL |
| 10mM | 0.33mL | 1.64mL | 3.29mL |
| 50mM | 0.07mL | 0.33mL | 0.66mL |
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