Biological Activity
SIRT1 activator. Inhibits proliferation of breast cancer cell lines expressing mutant p53. Induces G2/M cell cycle arrest and apoptosis in triple negative breast cancer cells (TNBCs) in vitro.
Technical Data
| M. Wt | 372.18 |
| Formula | C19H21BO7 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1215281-19-8 |
| PubChem ID | 24881094 |
| InChI Key | AKNGHUAJAODDJA-FNORWQNLSA-N |
| Smiles | O=C(/C=C/C1=CC=C(OC)C(B(O)O)=C1)C2=CC(OC)=C(OC)C(OC)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.22 | 100 | |
| ethanol | 37.22 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 372.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.69 mL | 13.43 mL | 26.87 mL |
| 5 mM | 0.54 mL | 2.69 mL | 5.37 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.69 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Yi et al (2013) Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells. Oncotarget 4 984 PMID: 23846322
Ponnusamy et al (2015) Activation of sirtuin-1 promotes renal fibroblast activation and aggravates renal fibrogenesis. J.Pharmacol.Exp.Ther 354 142 PMID: 26022003
Keywords: YK 3-237, supplier, YK3-237, SIRT1, sirtuins, activators, activates, deacetylases, antiproliferative, Sir2-like, Family, Deacetylases, Sir2-like, Family, Deacetylases, Tocris Bioscience
